Amelioration of aluminium-induced liver damage by vitamin E
| Autor: | Kutlubay, R., Oguz, E. O., Abban, G., Sebahat Turgut |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
inorganic chemicals
Male antioxidant animal experiment liver sinusoid randomization alpha tocopherol complex mixtures Sensitivity and Specificity animal tissue Random Allocation Reference Values biochemistry oxidative stress Animals Vitamin E controlled study rat Drug Interactions Rats Wistar aluminum sulfate nonhuman animal model Liver Diseases Biopsy Needle article liver cell respiratory system Immunohistochemistry respiratory tract diseases Rats Disease Models Animal Liver sodium chloride Dietary Supplements cytoplasm histopathology microscopy Alum Compounds dietary intake Injections Intraperitoneal cell structure liver injury |
| Zdroj: | Scopus-Elsevier Web of Science |
| Popis: | Objective: To investigate the effects of aluminium sulphate on the microscopic morphology of the liver and on vitamin E amelioration of aluminium-induced liver damage. Methods: Rats were injected intraperitoneally with aluminium sulphate alone or aluminiurn sulphate together with vitamin F, with saline injected rats used as the control group. The study took place in Pamukkale University Faculty of Medicine in 2005. Results: The rats exposed to aluminiurn showed morphological changes in addition to previously reported biochemical changes in the liver. The antioxidant vitamin E significantly diminished the liver damage seen due to aluminium. Conclusion: There is an apparent protective effect of vitamin E on parenteral aluminiurn exposure. |
| Databáze: | OpenAIRE |
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