Under pressure: Adolescent substance users show exaggerated neural processing of aversive interoceptive stimuli
| Autor: | Berk, L, Stewart, JL, May, AC, Wiers, RW, Davenport, PW, Paulus, MP, Tapert, SF |
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| Přispěvatelé: | Ontwikkelingspsychologie (Psychologie, FMG) |
| Rok vydání: | 2015 |
| Předmět: |
Male
cannabis Drug Abuse (NIDA Only) Pediatric Research Initiative Alcohol Drinking Adolescent Marijuana Smoking Neuropsychological Tests interoception Basic Behavioral and Social Science Medical and Health Sciences Anticipation Mental Processes Clinical Research Behavioral and Social Science Humans Craving Cerebral Cortex Pediatric Analysis of Variance alcohol Respiration fMRI Psychology and Cognitive Sciences Neurosciences Substance Abuse Carbon Dioxide breathing load Adolescence Brain Disorders Cross-Sectional Studies Psychological Female Mental health Photic Stimulation Psychomotor Performance |
| Zdroj: | Addiction, vol 110, iss 12 Berk, L; Stewart, JL; May, AC; Wiers, RW; Davenport, PW; Paulus, MP; et al.(2015). Under pressure: Adolescent substance users show exaggerated neural processing of aversive interoceptive stimuli. Addiction. doi: 10.1111/add.13090. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/3dd8k18c Addiction (Abingdon, England), vol 110, iss 12 Addiction, 110(12), 2025-2036. Wiley-Blackwell Berk, L; Stewart, JL; May, AC; Wiers, RW; Davenport, PW; Paulus, MP; et al.(2015). Under pressure: Adolescent substance users show exaggerated neural processing of aversive interoceptive stimuli. Addiction, 110(12), 2025-2036. doi: 10.1111/add.13090. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/71b7h7hd |
| ISSN: | 0965-2140 |
| Popis: | © 2015 Society for the Study of Addiction. Aims: Adolescents with substance use disorders (SUD) exhibit hyposensitivity to pleasant internally generated (interoceptive) stimuli and hypersensitivity to external rewarding stimuli. It is unclear whether similar patterns exist for aversive interoceptive stimuli. We compared activation in the insular cortex and other brain regions during the anticipation and experience of aversive stimuli between adolescents with SUD and those without. Design: Cross-sectional experimental study with two groups. Participants: Adolescents (ages 15-17years) with an alcohol or marijuana SUD (n=18) and healthy comparison subjects (CON, n=15).Participants were recruited by distributing flyers at local high schools. Setting: Keck Imaging Center, University of California San Diego, CA, USA. Measurements: Behavioral and neural responses to a continuous performance task with inspiratory breathing load recorded during an fMRI session. Questionnaires assessed life-time drug use, anxiety, sensation-seeking, impulsivity, affect and bodily awareness. Visual analog scales assessed drug craving and breathing load responses. Findings: Across subjects, experience of breathing load elicited greater bilateral anterior and posterior insula (AI and PI, respectively) activation than anticipation (F(1,31)=4.16, P |
| Databáze: | OpenAIRE |
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