Renin- angiotensin system in control of vascular reactivity
| Autor: | Drenjančević-Perić, Ines, Gros, Mario |
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| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: | |
| Zdroj: | Medicinski Glasnik, Vol 3, Iss 1, Pp 1-9 (2006) |
| ISSN: | 1840-2445 1840-0132 |
| Popis: | This paper aimed to present recent knowledge of the role of the renin-angiotensin system (RAS) in the control of vascular relaxation mechanisms and the relation to development and maintenance of hypertension. The emphasisis given on the role of oxidative stress and NO – dependent and prostanoid - dependent vascular relaxation mechanisms that are impaired in SS salt-sensitive rat strain (that exhibit chronically low plasma renin activity), and restored in consomic SS.13BN rats (that have chromosome 13, containing renin gene, introgressed from BN rat into SS genetic background). In conclusion, results of numerous experimental studies suggest that hypoactive (as well as hyperactive) RAS may contribute to development and maintenance of hypertension due to the effects of angiotensin II on vascular reactivity. |
| Databáze: | OpenAIRE |
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