Contrast-enhancing tumor growth dynamics of preoperative, treatment-naive human glioblastoma
| Autor: | Ellingson, BM, Nguyen, HN, Lai, A, Nechifor, RE, Zaw, O, Pope, WB, Yong, WH, Nghiemphu, PL, Liau, LM, Cloughesy, TF |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Time Factors Oncology and Carcinogenesis Contrast Media Growth and over Young Adult Rare Diseases 80 and over Humans Oncology & Carcinogenesis Aged Cancer volumetry Brain Neoplasms T1 subtraction glioblastoma growth rates Middle Aged Magnetic Resonance Imaging Tumor Burden Brain Disorders Brain Cancer Preoperative Period Public Health and Health Services Biomedical Imaging Female Follow-Up Studies |
| Zdroj: | Cancer, vol 122, iss 11 Ellingson, BM; Nguyen, HN; Lai, A; Nechifor, RE; Zaw, O; Pope, WB; et al.(2016). Contrast-Enhancing Tumor Growth Dynamics of Preoperative, Treatment-Naive Human Glioblastoma. CANCER, 122(11), 1718-1727. doi: 10.1002/cncr.29957. UCLA: Retrieved from: http://www.escholarship.org/uc/item/1bt317dx |
| DOI: | 10.1002/cncr.29957. |
| Popis: | BackgroundLittle is known about the natural growth characteristics of untreated glioblastoma before surgical or therapeutic intervention, because patients are rapidly treated after preliminary radiographic diagnosis. Understanding the growth characteristics of uninhibited human glioblastoma may be useful for characterizing changes in response to therapy. Thus, the objective of the current study was to explore tumor growth dynamics in a cohort of patients with untreated glioblastoma before surgical or therapeutic intervention.MethodsNinety-five patients with glioblastoma who had measurable enhancing disease on >2 magnetic resonance imaging scans before surgery were identified. Tumor growth rates were quantified in 4 different ways (the percentage change per day, the absolute rate of change per day, the estimated volumetric doubling time, and the radial expansion rate) using 3 different approaches (bidirectional product, enhancing disease, and total lesion volume).ResultsThe median volumetric doubling time was 21.1 days, the percentage change in tumor volume was 2.1% per day, and the rate of change in total lesion volume was 0.18 cc per day. The length of follow-up between magnetic resonance imaging examinations should be >28 days to detect progressive disease with high specificity. Small initial tumor sizes ( |
| Databáze: | OpenAIRE |
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