Blood-CSF barrier and compartmentalization of CNS cellular immune response in HIV infection
| Autor: | de Almeida, Sérgio M, Rotta, Indianara, Ribeiro, Clea E, Smith, Davey, Wang, Ruiyi, Judicello, Jennifer, Potter, Michael, Vaida, Florin, Letendre, Scott, Ellis, Ronald J, HNRC Group |
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| Rok vydání: | 2016 |
| Předmět: |
Central Nervous System
Adult Male Pediatric AIDS Immunology Subtype HIV Infections HIV-associated neurocognitive disorders Clinical Research Humans 2.1 Biological and endogenous factors Aetiology Inflammation Pediatric Neurology & Neurosurgery HNRC Group Neurosciences virus diseases Middle Aged Cross-Sectional Studies Cerebrospinal fluid Infectious Diseases Mental Health Good Health and Well Being Blood-Brain Barrier Blood-CSF barrier HIV-1 RNA Cytokines HIV/AIDS Female Infection Biomarkers |
| Zdroj: | de Almeida, SM; Rotta, I; Ribeiro, CE; Smith, D; Wang, R; Judicello, J; et al.(2016). Blood-CSF barrier and compartmentalization of CNS cellular immune response in HIV infection. JOURNAL OF NEUROIMMUNOLOGY, 301, 41-48. doi: 10.1016/j.jneuroim.2016.10.009. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/5mf0q45h |
| DOI: | 10.1016/j.jneuroim.2016.10.009. |
| Popis: | HIV infection is persistent in the CNS, to evaluate the compartmentalization of the CNS immune response to HIV, we compared soluble markers of cellular immunity in the blood and CSF among HIV- (n=19) and HIV+ (n=68), as well as among HIV participants with or without CSF pleocytosis. Dysfunction of the blood cerebrospinal fluid barrier (BCSFB) was common in HIV participants. CSF levels of TNFα, IFNγ, IL-2, IL-6, IL-7, IL-10, IP-10, MIP-1α, MIP-1β, and RANTES were significantly higher in participants with CSF pleocytosis (P |
| Databáze: | OpenAIRE |
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