Rule-Based Modelling and Simulation of Drug-Administration Policies
| Autor: | Bortolussi, L., Krüger, T., Thorsten Lehr, Wolf, V. |
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| Přispěvatelé: | K. Rupp, W. Thacker, L. T. Watson, M. Sosonkina, Bortolussi, Luca, Kruger, Thilo., Wolf, Verena, Lehr, Thorsten |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Scopus-Elsevier |
| Popis: | We investigate a model of drug administration in the con- text of a plaque-formation process responsible of Alzheimer’s disease. This is a polymerisation process, best described by a rule-based model to counteract the intrinsic combinatorial explosion of the underlying re- action network. Furthermore, there is the additional complicancy of time- dependent rates, modelling the effect of drugs. In the paper, we provide a novel and efficient rejection-based simulation algorithm that samples exactly the trajectory space and apply it to study the efficacy of different drug administration policies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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