Hypoxia in the Initiation and Progression of Neuroblastoma Tumours
| Autor: | Huertas-Castaño, Carlos, Gómez-Muñoz, María A., Pardal, Ricardo, Vega, Francisco M. |
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| Přispěvatelé: | Ministerio de Economía y Competitividad (España), European Commission, Asociación NEN, [Huertas-Castaño,C, Gómez-Muñoz,MA, Pardal,R, Vega,FM] Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain. [Huertas-Castaño,C, Pardal,R] Departamento de Fisiología Médica y Biofísica, Universidad de Sevilla, Seville, Spain. [Vega,FM] Departamento de Biología Celular, Universidad de Sevilla, Seville, Spain., This research was funded by the Spanish Ministry of Science and Innovation SAF program (grant number SAF2016-80412-P) co-funded by FEDER funds. MAG is supported by a fellowship from the 'Asociación Niños Enfermos de Neuroblastoma (NEN). |
| Rok vydání: | 2020 |
| Předmět: |
Células madre neoplásicas
Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Differentiation [Medical Subject Headings] Paediatric oncology Diseases::Pathological Conditions Signs and Symptoms::Pathologic Processes::Disease Attributes::Disease Progression [Medical Subject Headings] Neural crest cells Cancer stem cells Anatomy::Embryonic Structures::Neural Crest [Medical Subject Headings] Pediatría Phenomena and Processes::Genetic Phenomena::Genetic Structures::Base Sequence::Regulatory Sequences Nucleic Acid::Gene Regulatory Networks [Medical Subject Headings] Hipoxia tumoral Disciplines and Occupations::Health Occupations::Medicine::Internal Medicine::Medical Oncology [Medical Subject Headings] Oncología médica Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings] Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Models Theoretical [Medical Subject Headings] Neuroblastoma Disciplines and Occupations::Health Occupations::Medicine::Pediatrics [Medical Subject Headings] Diseases::Neoplasms::Neoplastic Processes::Neoplasm Metastasis [Medical Subject Headings] Cresta neural Hipoxia Persons::Persons::Age Groups::Child [Medical Subject Headings] Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms Glandular and Epithelial::Neoplasms Neuroepithelial::Neuroectodermal Tumors Primitive::Neuroectodermal Tumors Primitive Peripheral::Neuroblastoma [Medical Subject Headings] Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Respiration::Cell Hypoxia [Medical Subject Headings] Hypoxia |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| Popis: | This article belongs to the Special Issue Neuroblastoma Molecular Biology and Therapeutics. Neuroblastoma is the most frequent extracranial solid tumour in children, causing 10% of all paediatric oncology deaths. It arises in the embryonic neural crest due to an uncontrolled behaviour of sympathetic nervous system progenitors, giving rise to heterogeneous tumours. Low local or systemic tissue oxygen concentration has emerged as a cellular stimulus with important consequences for tumour initiation, evolution and progression. In neuroblastoma, several evidences point towards a role of hypoxia in tumour initiation during development, tumour cell differentiation, survival and metastatic spreading. However, the heterogeneous nature of the disease, its developmental origin and the lack of suitable experimental models have complicated a clear understanding of the effect of hypoxia in neuroblastoma tumour progression and the molecular mechanisms implicated. In this review, we have compiled available evidences to try to shed light onto this important field. In particular, we explore the effect of hypoxia in neuroblastoma cell transformation and differentiation. We also discuss the experimental models available and the emerging alternatives to study this problem, and we present hypoxia-related therapeutic avenues being explored in the field. This research was funded by the Spanish Ministry of Science and Innovation SAF program (grant number SAF2016-80412-P) co-funded by FEDER funds. MAG is supported by a fellowship from the “Asociación Niños Enfermos de Neuroblastoma (NEN). |
| Databáze: | OpenAIRE |
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