Effects of Water, Sanitation, Handwashing, and Nutritional Interventions on Child Enteric Protozoan Infections in Rural Bangladesh: A Cluster-Randomized Controlled Trial
| Autor: | Lin, A, Ercumen, A, Benjamin-Chung, J, Arnold, BF, Das, S, Haque, R, Ashraf, S, Parvez, SM, Unicomb, L, Rahman, M, Hubbard, AE, Stewart, CP, Colford, JM, Luby, SP |
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| Rok vydání: | 2018 |
| Předmět: |
Giardiasis
Adult Rural Population Male Adolescent sanitation Clinical Trials and Supportive Activities water Cryptosporidiosis Nutritional Status Medical and Health Sciences Microbiology Vaccine Related Feces Young Adult hygiene Clinical Research parasitic diseases Prevalence Humans Cluster Analysis 2.2 Factors relating to the physical environment Aetiology Child Preschool Nutrition Pediatric Bangladesh Protozoan Infections Entamoebiasis Prevention Giardia Middle Aged Biological Sciences Foodborne Illness Intestinal Diseases Emerging Infectious Diseases Infectious Diseases Clean Water and Sanitation Parasitic Female Pregnant Women Digestive Diseases Infection Hand Disinfection |
| Zdroj: | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, vol 67, iss 10 Lin, A; Ercumen, A; Benjamin-Chung, J; Arnold, BF; Das, S; Haque, R; et al.(2018). Effects of Water, Sanitation, Handwashing, and Nutritional Interventions on Child Enteric Protozoan Infections in Rural Bangladesh: A Cluster-Randomized Controlled Trial.. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 67(10), 1515-1522. doi: 10.1093/cid/ciy320. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/8sd0933s |
| DOI: | 10.1093/cid/ciy320. |
| Popis: | Background:We evaluated effects of individual and combined water, sanitation, handwashing (WSH), and nutritional interventions on protozoan infections in children. Methods:We randomized geographical clusters of pregnant women in rural Bangladesh into chlorinated drinking water, hygienic sanitation, handwashing, nutrition, combined WSH, nutrition plus WSH (N+WSH), or control arms. Participants were not masked. After approximately 2.5 years of intervention, we measured Giardia, Cryptosporidium, and Entamoeba histolytica prevalence and infection intensity by multiplex real-time polymerase chain reaction of child stool. Analysis was intention-to-treat. Results:Between May 2012 and July 2013, we randomized 5551 pregnant women. At follow-up, among 4102 available women, we enrolled 6694 children into the protozoan assessment. We analyzed stool from 5933 children (aged ~31 months) for protozoan infections. Compared with 35.5% prevalence among controls, Giardia infection prevalence was lower in the sanitation (26.5%; prevalence ratio [PR], 0.75 [95% confidence interval {CI}, .64-.88]), handwashing (28.2%; PR, 0.80 [95% CI, .66-.96]), WSH (29.7%; PR, 0.83 [95% CI, .72-.96]), and N+WSH (26.7%; PR, 0.75 [95% CI, .64-.88]) arms. Water and nutrition interventions had no effect. Low prevalence of E. histolytica and Cryptosporidium ( |
| Databáze: | OpenAIRE |
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