Sequence and evolution of the human germline V-lambda repertoire

Autor: Williams, S. C., Frippiat, J.-P., Tomlinson, I. M., Ignatovich, O., Lefranc, M. P., Winter, G.
Přispěvatelé: Skidaway Institute of Oceanography, Institute of Oceanography, Institut de Génétique Moléculaire de Montpellier (IGMM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)
Jazyk: angličtina
Rok vydání: 1996
Předmět:
Zdroj: Journal of Molecular Biology
Journal of Molecular Biology, Elsevier, 1996, 264 (2), pp.220--232. ⟨10.1006/jmbi.1996.0636⟩
ISSN: 0022-2836
1089-8638
Popis: We recently completed a map of the human immunoglobulin lambda (IGL) locus on chromosome 22q11.2 and showed that the V-lambda genes are arranged in three distinct clusters, each containing members of different V-lambda families. We have now sequenced each of these V-lambda genes and determined which are functional by comparison with the expressed repertoire. Our analysis indicates that there are approximately 30 functional V-lambda genes, depending on the haplotype, that belong to ten V-lambda families (five V(lambda)1, five V(lambda)2, eight V(lambda)3, three V(lambda)4, three V(lambda)5, one V(lambda)6, two V(lambda)7, one V(lambda)8, one V(lambda)9 and one V(lambda)10). V-lambda genes related to the major human V-lambda families (V(lambda)1, V(lambda)2 and V(lambda)3) predominate in species that express mainly lambda light chains. (C) 1996 Academic Press Limited
Databáze: OpenAIRE
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