Dose- and Time-dependent Effects of Permethrin on HepG2 Cells: Cell Survival, Lipid Peroxidation and Antioxidant Defence System

Autor:	Guvenc, Dilek, Gulbahar, M. Yavuz, Yavuz, Oguzhan, Guvenc, Tolga
Přispěvatelé:	OMÜ
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	permethrin HepG2 hepg2 Oxidative stress Cytotoxicity Veterinary medicine SF600-1100 cytotoxicity oxidative stress Permethrin
Zdroj:	Kafkas Universitesi Veteriner Fakultesi Dergisi, Vol 26, Iss 2, Pp 263-268 (2020)
ISSN:	1309-2251 1300-6045
Popis:	WOS: 000508967700015 There is very limited knowledge about in vitro hepatotoxicity of permethrin concerning dose and duration even though humans and nontargeted beings are exposed. In this study, three different doses of permethrin (1 mu M, 10 mu M, 100 mu M) were administered in three different time periods (24, 48, 72 h) and cell viability (WST-1 and Trypan blue test), lipid peroxidation (high performance lipid chromatography), and antioxidant (SOD-1, SOD-2 and GPx-1) gene expression levels (real time PCR) were evaluated. The LC50 dose of permethrin was calculated as 1111 mu M. Significant decrease in cell viability was detected in every time period except at the lowest dose (P
Databáze:	OpenAIRE
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