| Autor: |
Krasnyuk I., Beliatskaya A., Stepanova O., Korol L., Valeeva A., Grikh V., Ovsyannikova L., Kosheleva T. |
| Rok vydání: |
2017 |
| Předmět: |
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| Zdroj: |
SCOPUS21911630-2017-7-2-SID85019103499 |
| Popis: |
© 2016, Springer Science+Business Media New York.In this work, we studied water solubility of ampicillin trihydrate and its solid dispersions (SD) with polyethylene glycol-1500, polyvinylpyrrolidone-10000, and β-cyclodextrin. It was found that SD formation increases the solubility by a factor of 1.34–1.73 and the rate of ampicillin dissolution by a factor of 3.43–7.40. The results of complex physicochemical studies suggest that the improved release of ampicillin from SD is due to its micronization and solubilization by the polymer. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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