FRAX in Haemodialysis Patients: Preliminary Results

Autor: Draško Pavlović, Sonja Dits, Dijana Knežević Strinavić, Slava Doko, Ivančica Hršak, Boris Kudumija
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Acta Clinica Croatica, Vol 60., Iss Supplement 1, Pp 13-17 (2021)
Acta clinica Croatica
Volume 60.
Issue Supplement 1
ISSN: 1333-9451
0353-9466
Popis: The incidence of bone fractures is several times higher in haemodialysis (HD) patients than in the general population. FRAX is a fracture risk evaluation tool and shows a 10-year probability of bone fracture. The aim of this study was to evaluate the FRAX score in haemodialysis patients. The study included 214 HD patients (81 female). We used the following calculation tool: https://www.sheffield.ac.uk/FRAX/?lang=cr. Increased risk for major fracture (MF) was defined as FRAX > 20% and for hip fracture (HF) > 3%. If renal osteodystrophy (ROD) is defined as primary osteoporosis, the average FRAX value for MF is 7.4 ± 6.4% and for HF 3.5 ± 4.1%, and as secondary osteoporosis, the average FRAX value for MF is 10.3 ± 8.4 %, for HF 5.4 ± 5.9%. 13.6% of patients or 49.1% had an increased risk for MF or HF if ROD was defined as secondary osteoporosis. If it was defined as primary osteoporosis, the results were 7.1% for MF or 39.2% for HF. In women, FRAX values were significantly higher for both HF and MF. According to our preliminary results, a large number of patients have an increased FRAX score risk, especially if we define ROD as secondary osteoporosis. The FRAX score is higher in women.
Učestalost prijeloma kosti nekoliko je puta veća u bolesnika na dijalizi (HD) nego u ostaloj populaciji. FRAX je alat za evaluaciju rizika prijeloma i prikazuje 10-godišnju vjerojatnost prijeloma kosti. Cilj rada je evaluacija vrijednosti FRAX u bolesnika na hemodijalizi. U ispitivanje je uključeno 214 HD bolesnika (81 žena). Rabili smo alat za izračun: https://www.sheffield.ac.uk/ FRAX/?lang=cr. Povišeni rizik za velike prijelome (VP) definiran je kao FRAX > 20 %, a za prijelom kuka (PK) > 3 %. Ako renalnu osteodistrofiju (ROD) definiramo kao primarnu osteoporozu, prosječna FRAX vrijednost za VP je 7,4±6,4 % a za PK 3,5± 4,1 %, a kao sekundarnu osteoporozu prosječna FRAX vrijednost za VP je 10,3±8,4 %, za PK 5,4± 5,9 %, 13,6 % bolesnika odnosno 49,1 % imalo je povišeni rizik za VP odnosno PK ako je ROD definiran kao sekundarna, a kao primarna osteoporoza 7,1 % za VP odnosno 39,2 % za PK. U žena FRAX vrijednosti su bile značajno više za PK i VP, 8,5±7,6 % odnosno 15.9 ± 10,4 %, kao sekundarna, te 4,8 ± 5,2, i 10,3±8,2 % kao primarna osteoporoza. Prema preliminarnim rezultatima veliki broj bolesnika ima povišene vrijednosti FRAX-a, posebno ako ROD definiramo kao sekundarnu osteoporou. Vrijednosti FRAXA-a su više u žena.
Databáze: OpenAIRE
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