| Popis: |
Role of Protein Tyrosine Kinase Syk in Regulation of Myogenically Differentiated Stem Cell Death Syk protein is tyrosine kinase with various, sometimes opposite, functions in different cells and thereby is an attractive therapeutic target in the treatment of various diseases. However, Syk role in stem cells functioning is little explored. In the present study we investigated the participation of Syk in myogenic differentiation of muscle derived stem cells. The increase of Syk phosphorylation and the effect of its inhibition on phosphorylation of MAP kinases showed the possible involvement of Syk in the regulation of myogenic differentiation. Pro-survival function of Syk was shown in differentiated cells exposed to apoptosis inductors. Moreover, Syk caused retardation of the motility of muscle derived stem cells was demonstrated. |
