LIMBAL TRANSPLANTATION AS A METHOD OF LOCAL IMMUNE TOLERANCE INDUCTION IN HIGH RISK KERATOPLASTY

Autor:	Tonaeva, Kh D., Onishchenko, N. A., Sergey Borzenok
Jazyk:	ruština
Rok vydání:	2011
Předmět:	immune tolerance RD1-811 limbal mesenchymal stem cells Surgery keratoplasty
Zdroj:	Vestnik Transplantologii i Iskusstvennyh Organov, Vol 13, Iss 2, Pp 95-102 (2011) Publons
ISSN:	1995-1191
Popis:	Activation of destructive adaptive and inherited immunity is the main reason of graft opacification by high-risk keratoplasty. Approximately 46% of recipients from this group are absolute resistant to immunosuppressive therapy with glucocorticoids and cyclosporine A and need tolerization. Discovery of limbal mesenchymal stem cells that resemble phenotype of mesenchymal stem cells of bone marrow reveal the prospects of their use like inductors of local immune tolerance in high-risk keratoplasty. It will help to increase percentage of successful engraftment and shorten the period of medical immunosuppression.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::13cd3037e022852a2b45d72c82f1c6c9 https://journal.transpl.ru/vtio/article/view/381 Zobrazit plný text záznamu