| Autor: |
Ciccarelli, O, Thomas, DL, De Vita, E, Wheeler-Kingshott, CAM, Kachramanoglou, C, Kapoor, R, Leary, S, Matthews, L, Palace, J, Chard, D, Miller, DH, Toosy, AT, Thompson, AJ |
| Jazyk: |
angličtina |
| Rok vydání: |
2016 |
| DOI: |
10.1002/ana.23909 |
| Popis: |
Astrocytic necrosis is a prominent pathological feature of neuromyelitis optica (NMO) lesions and is clinically relevant. We report 5 NMO-related cases, all with longitudinally extensive lesions in the upper cervical cord, who underwent cervical cord 1H-magnetic resonance spectroscopy. Lower myo-inositol/creatine values, suggesting astrocytic damage, were consistently found within the NMO lesions when compared with healthy controls and patients with multiple sclerosis (MS), who showed at least 1 demyelinating lesion at the same cord level. Therefore, the in vivo quantification of myo-inositol may distinguish NMO from MS. This is an important step toward developing imaging markers for clinical trials in NMO. © 2013 American Neurological Association. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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