| Autor: |
Jeusic, M., Bukovac, Lt, Malcic, I., Lukic, Ik, Klara Dubravcic, Batinic, D. |
| Jazyk: |
angličtina |
| Rok vydání: |
2005 |
| Předmět: |
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| Zdroj: |
Web of Science |
| Popis: |
Introduction: Regulatory T (TR) cells play a mayor role in the homeostasis of the immune system. Different populations of TR cells have been described, including so-called “ naturally occurring” CD4+CD25+ T cells and IL-10-producing TR1 cells. Animal studies have shown that removal or inactivation of CD4+CD25+ T cells can break natural self-tolerance ; leading to development of autoimmune diseases, while reintroduction of this subset of T cells prevented diseases. Although the recent reports confirmed the role of TR cells in various human pathological conditions but surprisingly little is know about the TR cells in juvenile idiopathic arthritis (JIA). Aim: To explore the level of TR cells in peripheral blood of patients with JIA in relation to disease severity. Patients and Methods: Thirty-four JIA patients (20 with oligoarticular, 9 with polyarticular, and 5 with systemic JIA) and 23 healthy children were enrolled. The diagnosis was established according to the ILAR criteria. Peripheral blood samples were obtained in active and inactive phase of the disease and analysed by means of flow cytometry. The relative and absolute numbers of CD4+CD25+ cells, as well the cells with presumed TR phenotype (CD4+CD25++ and CD4+CD25++CCR4+) were measured. The groups were compared using ANOVA, followed by Student-Newman- Keuls post hoc test. The α -level was set at 0.05. The study was approved by the Ethics Committee of the Zagreb University School of Medicine. Results: Children with the systemic type of JIA had significantly higher levels of CD4+CD25+ lymphocytes than children with other types of JIA or the healthy controls (P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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