Gastroprotective properties of manganese chloride on acetic acid induced ulcer in Wistar rats
| Autor: | Salami, A. T., Ndukauba, N. G., Iyiola, T. O., Agbola, O. F., Oluwole, F. S., SAMUEL OLALEYE |
|---|---|
| Zdroj: | Scopus-Elsevier African Journal of Biomedical Research; Vol 17, No 2 (2014); 109-117 |
| ISSN: | 1119-5096 |
| Popis: | Drugs with multiple mechanisms of protective action may be effective in minimizing tissue injury during diseases. Manganese has shown varied positive biological properties in reverting diseased conditions. There is dearth of information regarding its effects on gastrointestinal integrity, hence the aim of this study. Seventy male Wistar rats used in this study were randomly assigned into 7 groups viz: Groups 1 – control, 2 – ulcer untreated rats, 3,4,5,6 and 7 received 50mg/kg, 100mg/kg Manganese, 40mg/kg Cimetidine, 1mg/kg Mistoprotol and 30mg/kg Omeprazol respectively. Two weeks oral treatment (in groups 3-7) began 3 days after laparotomy of which chronic gastric ulcer was induced using acetic acid. On days 7 and 14, gastric acid secretion was performed on animals (fasted for 24 hours) from each group and their stomachs were removed, weighed and scored for ulcer before histological evaluation. Data were analyzed using ANOVA & Student t-test and significant at p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|