Takayasu's arteritis in Turkey - Clinical and angiographic features of 248 patients
| Autor: | Bicakcigil, M., Aksu, K., Kamali, S., Ozbalkan, Z., Ates, A., Karadag, O., Ozer, H.T.E. |
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| Přispěvatelé: | Bicakcigil, M., Aksu, K., Kamali, S., Ozbalkan, Z., Ates, A., Karadag, O., Direskeneli, H., Yeditepe Üniversitesi, Çukurova Üniversitesi |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Male
Takayasu's arteritis demography Turkey Comorbidity pulmonary hypertension erythema nodosum angiography Raynaud phenomenon Prospective Studies Age of Onset tumor necrosis factor inhibitor Child fever azathioprine adult Remission Induction aorta arch syndrome article Middle Aged Prognosis aged aorta valve regurgitation appetite female arthritis priority journal syncope Drug Therapy Combination cerebrovascular accident headache Immunosuppressive Agents prospective study corticosteroid hypertension Adolescent heart infarction disease classification pericarditis methotrexate mycophenolic acid 2 morpholinoethyl ester Young Adult remission turkey (bird) blurred vision weakness follow up Humans controlled study human arthralgia limb pain Glucocorticoids leflunomide claudication renal artery carotid artery thorax pain dyspnea major clinical study subclavian artery Takayasu Arteritis clinical feature kidney artery stenosis heart palpitation cyclophosphamide weight reduction clinical protocol Clinical and angiographic features |
| ISSN: | 1964-6348 |
| Popis: | PubMedID: 19646348 Objective. Takayasu's arteritis (TA) is a chronic, inflammatory vasculitis affecting the aorta and its major branches. Although it is more prevalent in Far-East Asia, the distribution of the disease is worldwide with different vascular involvement patterns and clinical manifestations. The objective of this study was to evaluate the demographic, clinical, angiographic and prognostic features of TA patients in Turkey. Methods. Clinical and angiographic findings of 248 TA patients (228 female, 27 male) followed at 15 Rheumatology Centers were prospectively evaluated according to a predefined protocol. Results. The mean age was 40.1 years (30.2 years at the clinical onset). Clinical manifestations included constitutional symptoms in 66%, absent or diminished pulses in 88%, bruits in 77%, extremity pain in 69%, claudication in 48%, hypertension in 43% and cerebrovascular accidents (CVA) in 18% of the patients. Renal artery stenosis, aortic regurgitation and pulmonary hypertension were present in 26%, 33% and 12%, respectively. According to the new angiographic classification, type V (50.8%) and Type I (32%) were the most frequent types of involvement. Corticosteroids were the main treatment in 93% of the patients alone (9%) or in combination with immunosuppressive agents (84%). Most frequently preferred immunosuppressive agents were methotrexate (63%), azathioprine (22%) and cyclophosphamide (13%). Remission was observed at least once in 94% of the patients and sustained remission in 71% during follow-up. Conclusion. The demographical, clinical and angiographic findings of TA patients in our series were similar to those reported from Japan, Brazil and Colombia. Combination therapies with immunosuppressive agents were the preferred choice of treatment in Turkey. © Copyright Clinical and Experimental Rheumatology 2009. |
| Databáze: | OpenAIRE |
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