Clinical value of FDG PET/CT in screening for distant metastases in head and neck squamous cell carcinoma

Autor: Deurvorst, S E, Hoekstra, O S, Castelijns, J A, Witte, B I, Leemans, C R, de Bree, R
Přispěvatelé: Radiology and nuclear medicine, CCA - Imaging and biomarkers, Epidemiology and Data Science, APH - Methodology, Otolaryngology / Head & Neck Surgery, ACS - Heart failure & arrhythmias
Jazyk: angličtina
Rok vydání: 2018
Zdroj: Clinical Otolaryngology, 43(3), 875-881. Blackwell Publishing Ltd Oxford, UK
Deurvorst, S E, Hoekstra, O S, Castelijns, J A, Witte, B I, Leemans, C R & de Bree, R 2018, ' Clinical value of FDG PET/CT in screening for distant metastases in head and neck squamous cell carcinoma ', Clinical Otolaryngology, vol. 43, no. 3, pp. 875-881 . https://doi.org/10.1111/coa.13074
ISSN: 1749-4478
DOI: 10.1111/coa.13074
Popis: OBJECTIVES: The detection of distant metastases is of major importance in management of head and neck squamous cell carcinoma patients.DESIGN: All patients underwent 18 FDG PET/CT for the detection of distant metastases.SETTING: Retrospective single-centre study.PARTICIPANTS: Head and neck squamous cell carcinoma patients with high-risk factors for distant metastases.MAIN OUTCOME MEASURES: Accuracy of 18 FDG PET/CT for the detection of distant metastases using clinical development of distant metastases and a minimal follow-up of twelve months as reference standard. Comparison of overall survival between patients diagnosed with distant metastases during initial screening and patients diagnosed with distant metastases during follow-up.RESULTS: In 23 (12%) of the 190 patients, 18 FDG PET/CT detected distant metastases at screening. Sensitivity and negative predictive value were 46.2% (95% CI 32.6-59.7) and 82.6% (95% CI 76.8-88.5). No difference in median overall survival from the time of distant metastases detection was found between patients diagnosed with DM during work-up or during follow-up.CONCLUSIONS: In head and neck squamous cell carcinoma patients with high-risk factors, 18 FDG PET/CT has a high negative predictive value for the detection of distant metastases and should be used in daily clinical practice, although the sensitivity is limited when long-term follow-up is used as reference standard.
Databáze: OpenAIRE
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