| Autor: |
Lips, J.P.M., Sixma, J.J., Schiphorst, M.E. |
| Jazyk: |
angličtina |
| Rok vydání: |
1980 |
| Předmět: |
|
| Zdroj: |
Thrombosis Research, 17(1-2), 19. Elsevier |
| ISSN: |
0049-3848 |
| Popis: |
Administration of Ticlopidine to human volunteers resulted in a prolonged bleeding time and decreased or absent aggregation of platelets with collagen and epinephrine. Adenosine diphosphate (ADP) induced platelet aggregation was initiated by a normal shape change, but the rate of the first wave of aggregation had decreased. The second wave of aggregation was absent. ADP-binding to platelets of volunteers, consisted of two classes of binding sites:one with high affinity and one with low affinity, giving a curvilinear and a linear part in a concentration dependency curve. After Ticlopidine, the low affinity part of the curve had disappeared. Evidence will be presented that this is a specific Ticlopidine effect. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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