A preliminary study of the frequency of focal neurological deficits in HIV/AIDS patients seropositive for Toxoplasma gondii IgG in Lagos, Nigeria
| Autor: | Oshinaike, O. O., Okubadejo, N. U., Francis Ojini, Danesi, M. A. |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Nigerian Quarterly Journal of Hospital Medicine; Vol 20, No 3 (2010); 104-107 Scopus-Elsevier |
| ISSN: | 0189-2657 |
| Popis: | Background: Cerebral toxoplasmosis is a common cause of focal neurologic deficits in HIV/AIDS. Financial constraints and access to neuroradiological facilities limit definitive diagnosis and first-line treatments are largely expensive and cumbersome.ObjectiveThis study examined the frequency of focal neurological signs in HIV/AIDS patients with positive Toxoplasma gondii IgG antibodies (and thus at high risk of reactivation), and the relationship to CD4 count.Methods: Using a case-control design, T. gondii IgG serology was determined in 83 HIV/AIDS patients on HAART and 42 HIV seronegative controls. Neurological evaluation and CD4 count (mm3) was conducted in all subjects.Results: A total of 71 (85.5%) HIV/AIDS patients were seropositive for T. gondii IgG. The IgG seroprevalence was 84.8% for cases with CD4 count 200 (P=0.46). Of the cases with positive Toxoplasma antibodies, the frequency of neurological lateralizing signs was higher in those with CD4 count 200 (7.1%) (X2 = 4.90, Fisher exact P < 0.01). The mean CD4 count of cases with lateralizing signs was 113.7±113.9 in contrast to 254.0±218.9 in those without lateralizing signs (P < 0.01).Conclusion: In our study, a higher frequency of focal neurological signs was found in the T. gondii seropositive HIV/AIDS patients with a higher degree of immune compromise (CD4 count |
| Databáze: | OpenAIRE |
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