Contact sensitization to limonene and linalool hydroperoxides in Spain: a GEIDAC* prospective study
| Autor: | Deza, Gustavo, García-Bravo, Begoña, Silvestre, Juan F, Pastor-Nieto, Maria A, González-Pérez, Ricardo, Heras-Mendaza, Felipe, Mercader, Pedro, Fernández-Redondo, Virginia, Niklasson, Bo, Giménez-Arnau, Ana M, GEIDAC |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Adolescent linalool Acyclic Monoterpenes Linalool Política de drogas ilegales en España Young Adult fragrance allergy Cyclohexenes Prevalence Humans hydroperoxides Prospective Studies Aged Aged 80 and over Terpenes Hydrogen Peroxide Middle Aged Patch Tests Perfume Hydroperoxides Dermatitis de contacte Spain Dermatitis Allergic Contact Monoterpenes limonene Female Allergic contact dermatitis allergic contact dermatitis Oxidation-Reduction Limonene Fragrance allergy |
| Popis: | BACKGROUND: Limonene and linalool are common fragrance terpenes widely used in cosmetic, household and hygiene products. Their primary oxidation products formed after air exposure, the hydroperoxides, have been recognized as important contact haptens. OBJECTIVES: To investigate the prevalence of contact allergy to hydroperoxides of limonene (Lim-OOHs) and hydroperoxides of linalool (Lin-OOHs) in Spain, and to define the optimal concentration for screening in consecutive patients. METHODS: Three different concentrations of Lim-OOHs (0.1%, 0.2% and 0.3% pet.) and Lin-OOHs (0.25%, 0.5% and 1.0% pet.) were simultaneously tested in 3639 consecutive patients at 22 departments of dermatology in Spain. RESULTS: Lim-OOHs at 0.1%, 0.2% and 0.3% yielded positive patch test reactions in 1.4%, 3.4% and 5.1% of the tested patients, respectively; and Lin-OOHs at 0.25%, 0.5% and 1.0% yielded positive reactions in 1.3%, 2.9% and 4.9% of the tested patients, respectively. Few irritant (1.5-1.9%) and doubtful reactions (0.4-0.5%) to both terpene hydroperoxides were registered at the highest concentrations tested. CONCLUSIONS: Lim-OOHs and Lin-OOHs can be considered as common causes of contact allergy, and their inclusion in an extended baseline patch test series therefore seems to be appropriate. The patch test preparations of Lim-OOHs 0.3% pet. and Lin-OOHs 1.0% pet. are useful tools for screening of contact sensitization. |
| Databáze: | OpenAIRE |
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