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Introduction: clinical electrocardiography is an essential tool for the diagnosis of cardiovascular diseases, and at the same time a complex content to assimilate. The application of mnemonics for the teaching-educational process allows a simpler and more efficient memorization. Objective: to prepare an educational multimedia on clinical electrocardiography applying mnemonics Method: a technological innovation investigation was carried out at the University of Medical Sciences of Santiago de Cuba from September to December 2018. A validation was carried out using Delphi method by 30 experts and an evaluation by 351 third year medical students. Mediaware and object-oriented programming, Adobe Photoshop, Microsoft Office, Adobe Reader and Adobe Flash were used for the design. Results: 66,67 % of the teachers had an assistant teaching category and 46,67 % were Doctors of Pedagogical and / or Medical Sciences. For 98,78 % of the experts, multimedia is a didactic model, which provides complete and up-to-date information on the subject and all applicable in teaching. 100 % of students expressed that multimedia allows an adequate understanding of knowledge and that the level of ease of use is adequate. A significant increase (p |