The Centiloid project: Standardizing quantitative amyloid plaque estimation by PET
| Autor: | Klunk, WE, Koeppe, RA, Price, JC, Benzinger, TL, Devous, MD, Jagust, WJ, Johnson, KA, Mathis, CA, Minhas, D, Pontecorvo, MJ, Rowe, CC, Skovronsky, DM, Mintun, MA |
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| Rok vydání: | 2015 |
| Předmět: |
Amyloid
Positron emission tomography Aging Clinical Sciences Centiloid scale Bioengineering Neurodegenerative Alzheimer's Disease Amyloid imaging Computer-Assisted Standardize Alzheimer Disease Fluorodeoxyglucose F18 80 and over Acquired Cognitive Impairment Humans Pittsburgh compound B Image Interpretation Aged Plaque Aniline Compounds Neurosciences Brain Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) Middle Aged Brain Disorders Thiazoles Geriatrics Positron-Emission Tomography Calibration Biomedical Imaging Dementia Radiopharmaceuticals |
| Zdroj: | Alzheimer's and Dementia, vol 11, iss 1 Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 11, iss 1 Klunk, WE; Koeppe, RA; Price, JC; Benzinger, TL; Devous, MD; Jagust, WJ; et al.(2015). The Centiloid project: Standardizing quantitative amyloid plaque estimation by PET. Alzheimer's and Dementia, 11(1), 1-15.e4. doi: 10.1016/j.jalz.2014.07.003. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/10c3q27q |
| DOI: | 10.1016/j.jalz.2014.07.003. |
| Popis: | © 2015 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved. Although amyloid imaging with PiB-PET ([C-11]Pittsburgh Compound-B positron emission tomography), and now with F-18-labeled tracers, has produced remarkably consistent qualitative findings across a large number of centers, there has been considerable variability in the exact numbers reported as quantitative outcome measures of tracer retention. In some cases this is as trivial as the choice of units, in some cases it is scanner dependent, and of course, different tracers yield different numbers. Our working group was formed to standardize quantitative amyloid imaging measures by scaling the outcome of each particular analysis method or tracer to a 0 to 100 scale, anchored by young controls (≤45 years) and typical Alzheimer's disease patients. The units of this scale have been named "Centiloids." Basically, we describe a "standard" method of analyzing PiB PET data and then a method for scaling any "nonstandard" method of PiB PET analysis (or any other tracer) to the Centiloid scale. |
| Databáze: | OpenAIRE |
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