1H-NMR spectroscopy of cerebrospinal fluid of fetal sheep during hypoxia-induced acidemia and recovery
| Autor: | Cappellen van Walsum, A.M. van, Jongsma, H.W., Wevers, R.A., Nijhuis, J.G., Crevels, A.J., Engelke, U.F.H., Abreu, R.A. de, Moolenaar, S.H., Oeseburg, B., Nijland, R. |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
(Patho)Physiological
endocrinological and methabolic aspects [Prevention of disorders in human reproduction] Neuromuscular and neurometabolic disorders Bloeddrukregulatie weefseloxygenatie en inspanning Neuromusculaire en neurometabole aandoeningen Bloodpressure regulation tissue oxygenation and exercise Inborn errors of metabolism (Patho-)fysiologische endocriene en metabole aspecten. [Preventie van stoornissen in de menselijke voortplanting] Pediatric Oncology. Treatment of children with cancer Kinderoncologie. Behandeling van kinderen met kanker Erfelijke stofwisselingsziekten |
| Zdroj: | Pediatric Research, 52, 56-63 Pediatric Research, 52, 1, pp. 56-63 |
| ISSN: | 0031-3998 |
| Popis: | Item does not contain fulltext The purpose of the study was to investigate the sequence of processes occurring during and after hypoxia-induced acidemia. We used proton nuclear magnetic resonance spectroscopy, which provides an overview of metabolites in cerebrospinal fluid (CSF), reflecting neuronal metabolism and damage. The pathophysiological condition of acute fetal asphyxia was mimicked by reducing maternal uterine blood flow in 14 unanesthetized pregnant ewes. CSF metabolites were measured during hypoxia-induced acidemia, and during the following recovery period, including the periods at 24 and 48 h after the hypoxic insult. Maximum values of the following CSF metabolites were reached during severe hypoxia (pH |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|