UTJECAJ SPOLA FETUSA I PUŠENJA TE RODNOSTI MAJKE NA AFP I SLOBODNI beta-HCG U PLODOVOJ VODI UREDNIH TRUDNOĆA DRUGOG TROMJESEČJA
| Autor: | Brajenović-Milić, Bojana, Tišljarić, Dubravka, Petrović, Oleg, Prodan, Mirko, Ristić, Smiljana, Marout, Jasminka, Herman, Radoslav, Kapović, Miljenko |
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| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
free beta-hCG
BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Ginekologija i opstetricija amniotic fluid alpha-fetoprotein fetal sex parity smoking pušenje BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Gynecology and Obstetrics slobodni beta-hCG plodova voda alfa-fetoprotein spol fetusa paritet BIOMEDICINE AND HEALTHCARE. Basic Medical Sciences. Human Genetics Genomics and Proteomics BIOMEDICINA I ZDRAVSTVO. Temeljne medicinske znanosti. Genetika genomika i proteomika čovjeka |
| Zdroj: | Gynaecologia et perinatologia : journal for gynaecology, perinatology, reproductive medicine and ultrasonic diagnostics Volume 16 Issue 1 |
| ISSN: | 1330-0091 |
| Popis: | Cilj istraživanja. (1) Ispitati utjecaj pušenja i rodnosti (pariteta) majke i spola fetusa na razinu alfa-fetoproteina (AFP) i slobodne beta-podjedinice humanog korionskog gonadotropina (slobodni beta-hCG) u plodovoj vodi urednih trudnoća. (2) Ispitati korelacije između serumskih vrijednosti AFP i slobodnog beta-hCG i vrijednosti spomenutih biljega u plodovoj vodi. Ispitanice i metode. Ispitivanje je provedeno na 233 uzorka plodove vode koji su dobiveni amniocentezom u drugom tromjesečju trudnoće. U 75 slučajeva uzet je i uzorak krvi neposredno prije amniocenteze. Sve su trudnoće bile jednoplodne, urednog tijeka i ishoda, a kariotip ploda bio je uredan. Koncentracije AFP i slobodnog beta-hCG određivane su fluoroimunometrijskom metodom i izražene u multiples of median (MoM) za odgovarajući tjedan trudnoće. Rezultati. U plodovoj vodi trudnica pušačica utvrđena je statistički značajno niža razina slobodnog beta-hCG nego u nepušačica (p=0,033). Utjecaj pušenja na razinu AFP u plodovoj vodi nije utvrđen (p=0,113). Nasuprot tomu, spol fetusa je značajno utjecao na razinu slobodnog beta-hCG i AFP u plodovoj vodi: razina slobodnog beta-hCG je bila statistički značajno viša, a AFP značajno niža ako je fetus bio ženskog spola (p0,05 za oba biljega). Statistički značajna korelacija utvrđena je za koncentracije AFP (r=0,61; p Objective. The aim is to investigate the influence of mother’s smoking and parity and fetal sex on AFP and free beta-hCG in amniotic fluid and to examine the correlation between maternal serum and amniotic fluid marker concentrations. Methods. The study was performed on 233 second-trimester amniotic fluid samples. In 75 women, blood sample was taken immediately before amniocentesis too. All pregnancies were singleton with normal fetal karyotype and outcome. Concentrations of AFP and free beta-hCG were determined by fluoroimmunoassay and converted to MoM, according to medians for unaffected pregnancies of the corresponding gestational age. Results. In smoking women, amniotic fluid free beta-hCG was significantly lower than in non-smoking ones (p=0.033), though AFP was not significantly different in regard to smoking habits (p=0.113). Significantly higher amniotic fluid free beta-hCG (p |
| Databáze: | OpenAIRE |
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