Diabetes potentiates acetylcholine-induced relaxation in rabbit renal arteries
| Autor: | Alabadí Ferrer, José Antonio, Miranda Alonso, Francisco Javier, Lloréns, Silvia, Ruiz de Apodaca, Rosa F., Centeno Guil, José M., Alborch Domínguez, Enrique |
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| Rok vydání: | 2001 |
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| Zdroj: | Alabadí Ferrer, José Antonio Miranda Alonso, Francisco Javier Lloréns, Silvia Ruiz de Apodaca, Rosa F Centeno Guil, José M Alborch Dominguez, Enrique 2001 Diabetes potentiates acetylcholine-induced relaxation in rabbit renal arteries. European Journal of Pharmacology 415 225 232 RODERIC. Repositorio Institucional de la Universitat de Valéncia instname |
| Popis: | The response of rabbit renal arteries to acetylcholine and its endothelial modulation in diabetes were investigated. Acetylcholine induced concentration-related endothelium-dependent relaxation of renal arteries that was significantly more potent in diabetic rabbits than in control rabbits. Pretreatment with NG-nitro-L-arginine L-NOArg., indomethacin, or L-NOArg plus indomethacin induced partial inhibition of acetylcholine-induced relaxation. Inhibition induced by L-NOArg plus indomethacin was significantly higher in arteries from diabetic rabbits than in arteries from control rabbits. In renal arteries depolarised with KCl 30 mM and incubated with L-NOArg plus indomethacin, acetylcholine-induced relaxation was almost abolished in both groups of rabbits and this response was not different from that obtained in arteries without endothelium. Sodium nitroprusside induced concentration-dependent relaxation of renal arteries from control and diabetic rabbits without significant differences between the two groups of animals. These results suggest that diabetes potentiates the acetylcholine-induced relaxation in rabbit renal arteries. Increased release of nitric oxide and prostacyclin could be responsible for the enhanced relaxant potency of acetylcholine in diabetes. |
| Databáze: | OpenAIRE |
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