Subclinical myocardial disease by cardiac magnetic resonance imaging and spectroscopy in healthy HIV/Hepatitis C virus-coinfected persons
| Autor: | Chew, Kara W, Liu, Chia-Ying, Ambale-Venkatesh, Bharath, Liao, Diana, Horwich, Tamara B, Lima, João AC, Bluemke, David A, Paul Finn, J, Butt, Adeel A, Currier, Judith S |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Proton Magnetic Resonance Spectroscopy cardiac magnetic resonance imaging Chronic Liver Disease and Cirrhosis HIV Infections Hepacivirus heart disease Cardiovascular Medical and Health Sciences Hepatitis Hepatitis - C Clinical Research General & Internal Medicine Humans Chronic Coinfection Myocardium Spectrum Analysis myocardial steatosis Liver Disease virus diseases HIV Evaluation of treatments and therapeutic interventions Middle Aged Hepatitis C Magnetic Resonance Imaging magnetic resonance spectroscopy Emerging Infectious Diseases Infectious Diseases 6.1 Pharmaceuticals Linear Models Biomedical Imaging HIV/AIDS myocardial fibrosis Digestive Diseases Infection |
| Zdroj: | The Journal of international medical research, vol 45, iss 6 |
| Popis: | Objective The contribution of hepatitis C virus (HCV) infection to the risk of heart failure in human immunodeficiency virus (HIV)-coinfected persons is unknown. The objective was to characterize cardiac function and morphology in HIV-treated coinfected persons. Methods In a cross-sectional study, HIV-infected patients virologically suppressed on antiretroviral therapy without known cardiovascular disease or diabetes mellitus underwent cardiac magnetic resonance imaging and spectroscopy for measures of cardiac function, myocardial fibrosis, and steatosis. Results The study included 18 male patients with a median age of 44 years. Of these, 10 had untreated HCV coinfection and eight had HIV monoinfection. Global systolic and diastolic function in the cohort were normal, and median myocardial fat content was 0.48% (interquartile range 0.35-1.54). Left ventricular (LV) mass index and LV mass/volume ratio were significantly greater in the HIV/HCV-coinfected group compared with the HIV-monoinfected group. In the HIV-monoinfected group, there was more myocardial fibrosis as measured by extracellular volume fraction. Conclusions There were differences between HIV/HCV-coinfected and HIV-monoinfected patients in cardiac structure and morphology. Larger studies are needed to examine whether HIV and HCV independently contribute to mechanisms of heart failure. |
| Databáze: | OpenAIRE |
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