Evaluation of venous thrombosis and tissue factor in epithelial ovarian cancer
| Autor: | Cohen, JG, Prendergast, E, Geddings, JE, Walts, AE, Agadjanian, H, Hisada, Y, Karlan, BY, Mackman, N, Walsh, CS |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Oncology and Carcinogenesis and over Thromboplastin Paediatrics and Reproductive Medicine Ovarian cancer Neoplasms Enzyme Multiplied Immunoassay Technique Ovarian Epithelial 80 and over Humans cardiovascular diseases Oncology & Carcinogenesis Neoplasm Staging Aged Clear cell carcinoma Ovarian Neoplasms Venous Thrombosis Carcinoma Glandular and Epithelial Middle Aged Immunohistochemistry Survival Analysis Tissue factor Case-Control Studies Female Microvesicles Venous thromboembolism |
| Zdroj: | Gynecologic oncology, vol 146, iss 1 Cohen, JG; Prendergast, E; Geddings, JE; Walts, AE; Agadjanian, H; Hisada, Y; et al.(2017). Evaluation of venous thrombosis and tissue factor in epithelial ovarian cancer. GYNECOLOGIC ONCOLOGY, 146(1), 146-152. doi: 10.1016/j.ygyno.2017.04.021. UCLA: Retrieved from: http://www.escholarship.org/uc/item/9tb0c7sf |
| DOI: | 10.1016/j.ygyno.2017.04.021. |
| Popis: | ObjectiveOvarian clear cell carcinoma (OCCC) and high grade serous ovarian cancer (HGSOC) are associated with the highest risk of VTE among patients with epithelial ovarian cancer (EOC). Tissue factor (TF) is a transmembrane glycoprotein which can trigger thrombosis. We sought to evaluate if there is an association between VTE and tumor expression of tissue factor (TF), plasma TF, and microvesicle TF (MV TF) activity in this high-risk population.MethodsWe performed a case-control study of OCCC and HGSOC patients with and without VTE. 105 patients who underwent surgery at a tertiary care center between January 1995 and October 2013 were included. Plasma TF was measured with an enzyme-linked immunosorbent assay. A TF-dependent Factor Xa generation assay was used to measure MV TF activity. Immunohistochemical (IHC) analysis was performed to evaluate tumor expression of TF.Results35 women with OCCC or HGSOC diagnosed with VTE within 9months of surgery were included in the case group. Those with VTE had a worse OS, p |
| Databáze: | OpenAIRE |
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