Protein tyrosine phosphatases: functional inferences from mouse models and human diseases

Autor:	Hendriks, W.J.A.J., Elson, A., Harroch, S., Stoker, A.W.
Rok vydání:	2008
Předmět:	Chemical and physical biology [NCMLS 7] Metabolism transport and motion [NCMLS 2] Functional Neurogenomics [DCN 2]
Zdroj:	FEBS Journal, 275, 5, pp. 816-30 FEBS Journal, 275, 816-30
ISSN:	1742-464X
Popis:	Contains fulltext : 71343.pdf (Publisher’s version ) (Closed access) Some 40-odd genes in mammals encode phosphotyrosine-specific, 'classical' protein tyrosine phosphatases. The generation of animal model systems and the study of various human disease states have begun to elucidate the important and diverse roles of protein tyrosine phosphatases in cellular signalling pathways, development and disease. Here, we provide an overview of those findings from mice and men, and indicate several novel approaches that are now being exploited to further our knowledge of this fascinating enzyme family.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::09f17011f2fcb33c524b0547349b5390 https://hdl.handle.net/2066/71343 Zobrazit plný text záznamu Plný text