Clinical Validation Of The Eleveld Propofol Pharmacokinetic-pharmacodynamic Model Used In General Anaesthesia
| Autor: | Remco Vellinga, Laura Hannivoort, Michel Struys, Anthony Absalom, Douglas Eleveld-Ufkes, Introna, M. |
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| Přispěvatelé: | Critical care, Anesthesiology, Peri-operative and Emergency medicine (CAPE) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Zdroj: | Clinical Validation Of The Eleveld Propofol Pharmacokinetic-pharmacodynamic Model Used In General Anaesthesia University of Groningen |
| Popis: | Background: Target-controlled infusion (TCI) systems are used to facilitate anesthetic drug administration. Current systems use pharmacokinetic models developed for specific patient groups. Their use in patients with different characteristics to that of the development population is therefore discouraged. Recently, Eleveld et al1 developed a propofol PK-PD model for broad application. The aim of the current study was to validate it in a broad range of patients, from children to the elderly, and in obese adults. Methods: The medical ethics committee of the University Medical Center Groningen (reference METc2018/216) approved the study. Four groups of 25 patients undergoing an elective surgical procedure were included. Eligibility criteria for the four groups were: children (age ≥ 3 years and |
| Databáze: | OpenAIRE |
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