Early detection of subtle motor dysfunction in cognitively normal subjects with amyloid- positivity

Autor: Mollica MA, Tort-Merino A, Navarra J, Irune Fernandez Prieto, Valech N, Olives J, León M, Lleó A, Martínez-Lage P, Sánchez-Valle R, Molinuevo JL, Rami L
Rok vydání: 2019
Předmět:
Zdroj: Cortex
r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Fundació Sant Joan de Déu
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname
ISSN: 0010-9452
Popis: Since the current neuropsychological assessments are not sensitive to subtle deficits that may be present in cognitively normal subjects with amyloid- positivity, more accurate and efficient measures are needed. Our aim was to investigate the presence of subtle motor deficits in this population and its relationship with cerebrospinal fluid (CSF) amyloid- levels. We adapted the Finger Tapping Task to measure tapping speed and intrasubject variability. Seventy-two right-handed participants completed the study. Subjects were divided into three groups according to their CSF biomarker profile: 37 control participants (negative CSF AD biomarkers, CTR), 20 cognitively normal subjects with amyloid- positivity (abnormal levels of CSF A 42 , A+) and 15 AD patients. All subjects underwent lumbar puncture for the CSF analysis, apolipoprotein E genotyping and completed the Finger Tapping Task, a neuropsychological battery and cardiovascular risk factor and physical activity assessments. An overall difference between groups was found both in tapping speed [F(2,66)=19.37, p.01] and in intrasubject variability [F(2,66)=11.40, p.01]. More specifically, the A+ group showed lower speed [F(1,52)=5.33, p.05] and greater intrasubject variability [F(1,52)=8.48, p.01] than the CTR group, and higher speed than the AD group [F(1,30)=13.61, p.01]. Speed (=.263, p.05) and intrasubject variability (=-.558, p.01) were significantly associated with CSF amyloid- levels. The present findings suggest that subtle motor difficulties can be detected in cognitively healthy subjects with amyloid- positivity and be related to CSF A 42 levels. An accurate assessment of motor functions could help on identifying individuals at the earliest stage of the Alzheimer's continuum.
Databáze: OpenAIRE
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