Increased expression of 5-lipoxygenase is common in clear cell renal cell carcinoma

Autor:	Faronato, M., Muzzonigro, G., Milanese, G., Menna, C., Anna Rita Bonfigli, Catalano, A., Procopio, A.
Rok vydání:	2007
Předmět:	616.6 - Patología del sistema genitourinario urologic and male genital diseases Tumor progression Renal cell carcinoma
Zdroj:	DIGITUM. Depósito Digital Institucional de la Universidad de Murcia instname Scopus-Elsevier
Popis:	The clinical behaviour of Clear Cell Renal Cell Carcinoma (CC-RCC) is often unpredictable. To fully understand the signaling pathways involved in CCRCC development, we examined whether the 5- Lipoxygenase (5-LO), which catalyzes the biosynthesis of proinflammatory leukotrienes, is involved in renal tumorigenesis. By analyzing 46 snap-frozen primary renal cell carcinomas and their corresponding normal renal cortex biopsies, 5-LO protein levels were found to be significantly increased in the majority of CC-RCCs (P4 cm) and age of patients (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::08c08229d36e01f342ddc402f3a822a2 http://hdl.handle.net/10201/27642 Zobrazit plný text záznamu