IMMUNOHISTOCHEMICAL EVALUATION of UVEAL MELANOCYTIC TUMORS - EXPRESSION of HMB-45, S-100 PROTEIN, and NEURON-SPECIFIC ENOLASE
| Autor: | Burnier Junior, Miguel Noel [UNIFESP], Mclean, I. W., Gamel, J. W. |
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| Přispěvatelé: | ARMED FORCES INST PATHOL, Universidade Federal de São Paulo (UNIFESP), UNIV LOUISVILLE |
| Jazyk: | angličtina |
| Rok vydání: | 1991 |
| Zdroj: | Repositório Institucional da UNIFESP Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
| Popis: | The authors compared the immunohistochemical reactivity of 13 uveal nevi and 20 uveal melanomas for HMB-45, S-100 protein, and neuron-specific enolase (NSE) in formalin-fixed, paraffin-embedded sections. All 33 of the lesions were positive for HMB-45. the false-negative rates for S-100 protein and NSE were 21% and 18%, respectively. If only strongly positive reactions were considered, more than 50% of the tumors would be interpreted as negative for S-100 protein and NSE. Nevi stained with less intensity than melanomas using all three antibodies. the expression of HMB-45 appeared to be greater in active nevi than in inactive nevi. There was a weak association between S-100 protein reactivity and the ability of the uveal melanomas to metastasize (P = 0.1); however, the standard deviation of nucleolar area was a much better predictor (P = 0.02). These results indicate that pathologists will find HMB-45 to be a useful tool in differentiating uveal melanoma from nonmelanocytic tumors. ARMED FORCES INST PATHOL,DEPT OPHTHALM,WASHINGTON,DC 20306 ESCOLA PAULISTA MED SCH,BRAZILIAN REGISTRY OPHTHALM PATHOL,BR-04023 São Paulo,BRAZIL UNIV LOUISVILLE,HLTH SCI CTR,SCH MED,DEPT OPHTHALMOL,LOUISVILLE,KY 40202 ESCOLA PAULISTA MED SCH,BRAZILIAN REGISTRY OPHTHALM PATHOL,BR-04023 São Paulo,BRAZIL Web of Science |
| Databáze: | OpenAIRE |
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