Oxygen enhanced-{MRI} detects radiotherapy-induced change in hypoxia in xenograft models and lung cancer patients
| Autor: | Ahmed Salem, Ross Little, Adam Featherstone, Muhammad Babur, Hitesh Mistry, Susan Cheung, Yvonne Watson, Victoria Tessyman, Marie-Claude Asselin, ALAN JACKSON, Kaye Williams, Geoff Parker, Corinne Faivre-Finn, Connor, James O. |
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| Zdroj: | University of Manchester-PURE Salem, A, Little, R, Featherstone, A, Babur, M, Mistry, H, Cheung, S, Watson, Y, Tessyman, V, Asselin, M-C, Jackson, A, Williams, K, Parker, G, Faivre-Finn, C & O'Connor, J 2018, Oxygen enhanced-{MRI} detects radiotherapy-induced change in hypoxia in xenograft models and lung cancer patients . in ISMRM 2018 . < http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/0123.html > |
| Popis: | Oxygen-enhanced MRI (OE-MRI) has shown promise as a technique for quantifying and spatially mapping tumour hypoxia. Here, we report a world first-in-man study showing that OE-MRI signals in perfused tumour can non-invasively track changes in hypoxia induced by radiotherapy. We show that OE-MRI detects (1) reduction in hypoxia in Calu6 xenografts and that this change is due to hypoxia modification; and (2) reduction in hypoxia is also seen in 14 patients with non-small cell lung cancer. These data support first-in-man use of OE-MRI biomarkers in clinical trials of (chemo)-radiotherapy as single agent or in combination with hypoxia-modifying agents. |
| Databáze: | OpenAIRE |
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