Comparing extracorporeal shock wave and hyaluronic acid in a rabbit cartilage defect model: the effects of ESW on cartilage defect
| Autor: | Oztemur, Zekeriya, Ozer, Hatice, Golge, Umut Hatay, Altuntas, Emine Elif, Bulut, Okay |
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| Přispěvatelé: | Sivas Cumhuriyet Üniversitesi, [Oztemur, Zekeriya -- Bulut, Okay] Cumhuriyet Univ, Fac Med, Dept Orthoped & Traumatol, Sivas, Turkey -- [Ozer, Hatice] Cumhuriyet Univ, Fac Med, Dept Pathol, Sivas, Turkey -- [Golge, Umut Hatay] Canakkale Onsekiz Mart Univ, Fac Med, Dept Orthoped & Traumatol, Canakkale, Turkey -- [Altuntas, Emine Elif] Cumhuriyet Univ, Fac Med, Dept Otolaryngol, Sivas, Turkey, Oztemur, Zekeriya -- 0000-0003-2134-8797 |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: | |
| Popis: | WOS: 000321481200024 Aim: To compare the efficiency of extracorporeal shock wave (ESW) treatment with hyaluronic acid (HA) viscosupplementation in an experimental rabbit cartilage defect model. Materials and methods: A total of 24 New Zealand rabbits were randomly divided into 4 groups: HA, ESW, ESW + HA, and control. Chondral defects were created in the left knees of the rabbits. HA viscosupplementation was performed on the HA and ESW + HA groups, and after 24 h, 0.16 mJ/mm2 ESW was performed on the ESW and ESW + HA groups. After an 8-week follow-up, the rabbits were sacrificed and histopathological examination of the defects was carried out. In addition, immunohistochemistry was performed by the avidin-biotin peroxidase method using vascular endothelial growth factor (VEGF), transforming growth factor beta 1 (TGF-beta 1), and type II collagen antibodies, and the results were evaluated semiquantitatively. Results: There was a significant difference between the control group and the ESW group in terms of Pineda score and type II collagen expression; between the control group and the HA group in terms of Pineda score, VEGF expression, type II collagen expression, and TGF-beta 1 expression; and between the control group and the ESW + HA group in terms of Pineda score, VEGF expression, type II collagen expression, and TGF-beta 1 expression. Conclusion: The results show that both treatment methods have positive therapeutic effects on the articular cartilage defect model in terms of the parameters studied. Cumhuriyet University Scientific Research Projects (CUBAP) Project [T-421] The present study was supported by Cumhuriyet University Scientific Research Projects (CUBAP) Project no T-421. |
| Databáze: | OpenAIRE |
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