High levels of soluble CD40 ligand and matrix metalloproteinase-9 in serum are associated with favorable clinical evolution in human visceral leishmaniasis

Autor: Oliveira, Fabrícia Alvisi de, Silva, Carla Vanessa Oliveira, Damascena, Nayra Prata, Passos, Rodrigo Oliveira, Duthie, Malcolm, Guderian, Jeffrey, Bhatia, Ajay, Moura, Tatiana Rodrigues de
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Zdroj: Repositório Institucional da UFS
Universidade Federal de Sergipe (UFS)
instacron:UFS
Popis: BACKGROUND: Soluble CD40 ligand (sCD40L) and matrix metalloproteinase 9 (MMP-9) are inflammation markers and have been poorly described in infectious disease. In this prospective study, we describe the sera kinetics of these two molecules in the course of treatment follow up in human visceral leishmaniasis (VL). METHODS: Sera from VL patients were collected before and during follow up of regular Antimony treatment. sCD40L and MMP-9 were measured by Luminex assay. Paired analysis by Wilcoxon signed test was used for comparison of values of the same subjects before and after initiation of treatment. Correlations between clinical data and parasite load with the serum levels of sCD40L and MMP-9 were performed by Spearman test. Tests were considered statistically significant if the probability of a type I error was less than 5% (p-value
Databáze: OpenAIRE