A Preliminary Study of Left Ventricular Rotational Mechanics in Children with Noncompaction Cardiomyopathy: Do They Influence Ventricular Function?
| Autor: | Nawaytou, Hythem M, Montero, Andrea E, Yubbu, Putri, Calderón-Anyosa, Renzo JC, Sato, Tomoyuki, O'Connor, Matthew J, Miller, Kelley D, Ursell, Philip C, Hoffman, Julien IE, Banerjee, Anirban |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
Torsion Cardiomyopathy Left Arrhythmias Cardiorespiratory Medicine and Haematology Cardiovascular Mechanics Pediatrics Clinical Research Ventricular Dysfunction Humans 2.1 Biological and endogenous factors Prospective Studies Noncompaction Child Heart Failure Pediatric Heart Disease Cardiovascular System & Hematology Echocardiography Case-Control Studies embryonic structures Female Cardiomyopathies Cardiac |
| Zdroj: | Nawaytou, HM; Montero, AE; Yubbu, P; Calderon-Anyosa, RJC; Sato, T; O'Connor, MJ; et al.(2018). A Preliminary Study of Left Ventricular Rotational Mechanics in Children with Noncompaction Cardiomyopathy: Do They Influence Ventricular Function?. JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY, 31(8), 951-961. doi: 10.1016/j.echo.2018.02.015. UCSF: Retrieved from: http://www.escholarship.org/uc/item/0xf2s1ws Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, vol 31, iss 8 |
| DOI: | 10.1016/j.echo.2018.02.015. |
| Popis: | BACKGROUND:Current diagnostic criteria for noncompaction cardiomyopathy (NCC) lack specificity, and the disease lacks prognostic indicators. Reverse apical rotation (RAR) with abnormal rotation of the cardiac apex in the same clockwise direction as the base has been described in adults with NCC. The aim of this study was to test the hypothesis that RAR might differentiate between symptomatic NCC and benign hypertrabeculations and might be associated with ventricular dysfunction. METHODS:Echocardiograms from 28 children with NCC without cardiac malformations were prospectively compared with those from 29 age-matched normal control subjects. A chart review was performed to identify the patients' histories and clinical characteristics. Speckle-tracking was used to measure longitudinal strain, circumferential strain, and rotation. RESULTS:RAR occurred in 39% of patients with NCC. History of left ventricular (LV) dysfunction or arrhythmia was universal in, but not exclusive to, patients with RAR. Patients with RAR had lower LV longitudinal strain but similar ejection fractions compared with patients without RAR (median, -15.6% [interquartile range, -12.9% to -19.3%] vs -19% [interquartile range, -14.5% to -21.9%], P < .01; 53% [interquartile range, 43% to 68%] vs 61% [interquartile range, 58% to 67%], P = .08). Only a pattern of contraction with RAR, early arrest of twisting by mid-systole, and premature untwisting was associated with lower ejection fraction (46%; interquartile range, 43% to 52%; P=.006). CONCLUSIONS:RAR is not a sensitive but is a specific indicator of complications in children with NCC. Therefore, RAR may have prognostic rather than diagnostic value. Premature untwisting of the left ventricle during ejection may be an even more worrisome indicator of LV dysfunction. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|