18F-Fluoride-based Molecular Calcium Deposition as biomarker of early and ongoing molecular calcification in the vascular walls in low, intermediate, and high cardiovascular risk subgroups
| Autor: | Fiz, F., Picori, L., Arnoldo Piccardo, Massollo, M., Pestarino, E., Marini, C., Ghigliotti, G., Cabria, M., Democrito, A., Lasaponara, A., Alavi, A., Sambuceti, G., Morbelli, S. |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Zdroj: | European journal of nuclear medicine and molecular imaging (Internet) 39 (2012): S251. info:cnr-pdr/source/autori:F. Fiz; L. Picori; A. Piccardo; M. Massollo; E. Pestarino; Cecilia Marini; G. Ghigliotti; M. Cabria; A. Democrito; A. Lasaponara; A. Alavi; Gianmario Sambuceti; S. Morbelli./titolo:18F-Fluoride-based Molecular Calcium Deposition as biomarker of early and ongoing molecular calcification in the vascular walls in low, intermediate, and high cardiovascular risk subgroups./doi:/rivista:European journal of nuclear medicine and molecular imaging (Internet)/anno:2012/pagina_da:S251/pagina_a:/intervallo_pagine:S251/volume:39 Publons |
| Popis: | Aim: To evaluate the potential of 18F-Fluoride PET in the detection of early and ongoing molecular calcification within the vascular walls. Methods: The present study included 63 oncologic patients (14 males, mean age 61.3±8.2 range 27- 81) who underwent 18F-Fluoride PET/CT imaging in the course of follow up for either breast or prostate cancer. Soon before imaging, all patients were administered with a questionnaire for cardiovascular risk stratification according to the Framingham model. The whole study group was thus subdivided into three risk categories: low (20%, n=14). In each patient, volumetric regions of interest (ROI) were drawn on three aortic segments (arch, thoracic and abdominal aorta), subclavian, carotid, iliac and femoral arteries, respectively. In these regions, average 18F-fluoride uptake was measured and normalized for the blood-pool radioactivity concentration to obtain target to background SUV ratio (SUVR).These same regions were used to estimate arterial calcium load (CL) at the co-registered CT images. Finally, Calcification Score (GMCS) for each patient was generated taking into account mean SUV of the entire heart and heart-volume on the CT-scan as previously validated (1). Results: The 14 high-risk patients showed the highest values of CL, average SUVR and GMCS (p |
| Databáze: | OpenAIRE |
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