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Attention-deficit/hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder. Its etiology is not clearly understood yet, but neurobiological, genetic and environmental factors are shown to play a role. The relationship between ADHD and miRNAs has been studied quite recently, and few studies have been conducted up to now. In this study, peripheral blood expression levels of miR-5692b, miR-let-7d, miR-124-3p, miR-4447 and miR-107 of 30 children and adolescents with combined type ADHD were compared to 30 healthy controls to understand the roles of these miRNAs in the ADHD etiopathogenesis. Compared to controls, levels of miR-5692b (p = 0.006) were found higher and levels of miR-let-7d (p = 0.017) were found lower in the ADHD group. There was no significant difference in terms of miR-124-3p, miR-4447, and miR-107 levels between the groups. In conclusion, our findings support other studies suggesting the importance of miRNAs in the pathogenesis of ADHD. Regarding the regulatory role of miRNAs in gene regulation, their contribution to etiopathogenesis and heterogeneity of ADHD should be investigated further. C1 [Aydin, Sezai Ustun] Denizli State Hosp, Child & Adolescent Psychiat Clin, Denizli, Turkey. [Basay, Burge Kabukcu] Pamukkale Univ, Sch Med, Dept Child & Adolescent Psychiat, Denizli, Turkey. [Cetin, Gokhan Ozan] Pamukkale Univ, Sch Med, Dept Med Genet, Denizli, Turkey. [Aydin, Aysegul Gungor] Pamukkale Univ, Sch Med, Dept Anat, Denizli, Turkey. [Tepeli, Emre] Next Genet Ctr, Istanbul, Turkey. |
