Comparative effectiveness of perindopril and losartan in patients with arterial hypertension and obesity
| Autor: | Nedogoda, S. V., Ledyaeva, A. A., Chumachek, E. V., Tsoma, V. V., Mazina, G. G., Salasyuk, A. S., Irina Barykina |
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| Zdroj: | Scopus-Elsevier ResearcherID Российский кардиологический журнал, Vol 0, Iss 1, Pp 63-69 (2012) |
| Popis: | Aim. To assess the antihypertensive effectiveness of perindopril А and losartan and their influence on the main cardiovascular risk factors among patients with arterial hypertension and obesity. Material and methods. This single-blind, randomised, comparative parallel study included patients either untreated with antihypertensive medications or in the end of the two-week wash-out period. All patients were randomised (random envelope method) into 2 groups: Group I (n=30) received perindopril А (Prestarium A, Servier; 10 mg/d), while Group II (n=30) was administered losartan (Cozaar, Merck Sharp & Dohme; 100 mg/d) for 24 weeks. The examination included 24-hour blood pressure monitoring (SpaceLabs 90207, USA), the measurement of pulse wave velocity (PWV), augmentation index, and central aortal pressure (Sphygmocor), and standard echocardiography (EchoCG) (ALOKA prosound L7 premier). Results. In the perindopril А group, 24-hour levels of systolic and diastolic blood pressure (SBP, DBP) decreased by 15,2% and 18,1%, respectively; in the losartan group, this reduction was 7,8% (p |
| Databáze: | OpenAIRE |
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