Biobased polyelectrolyte hydrogels as biosensing devices
| Autor: | Paz Cacheiro, José |
|---|---|
| Přispěvatelé: | Velasco Bayón, Diego, Hernández Velasco, Rebeca, Universidad Carlos III de Madrid. Departamento de Bioingeniería e Ingeniería Aeroespacial |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | e-Archivo. Repositorio Institucional de la Universidad Carlos III de Madrid instname |
| Popis: | The project “Biobased Polyelectrolyte Hydrogels as Biosensing Devices” studies the application as a biosensor and characterizes a hydrogel formed by the compaction of two natural polymers which are polyelectrolytes: ChS and gelatin. This gel presents a novel approach in the field of biomaterials since it is obtained from the centrifugation of the mix of two concentrations of opposite charged polyelectrolytes. Hydrogels that are synthesized in this way are called Compact Polyelectrolyte Complexes (CoPECs) and add some new promising properties to those of a common hydrogel. The fact that chemical crosslinkers are not needed for this type of hydrogels makes them more biocompatible and biodegradable, properties that are very interesting for the biomedical applications. CoPECs also present saloplastic behavior because are doped with NaCl which give the hydrogel the ability of being tunable when submerged in different salt concentrations. In the first place, the swelling ratio of the hydrogels was studied in order to obtain the response of the hydrogels to different NaCl concentrations. The second step was to evaluate their mechanical properties to determine the compression Young modulus of the material. Also, the possibility of changing the Young modulus with the different media is studied. For this purpose, a universal material tester and a rheometer were used. For the last step, the conductivity properties were measured using an electrolytic chamber in order to determine the capacity of the gels. Also, the different concentrations were considered to designe the experiment. For the conductivity measurements, the obtention of the graphene electrodes was also carried out in the lab. The results determined the characterization of the hydrogel as well as the different behavior that the they adopt when they are submerged in different NaCl concentrations. These properties may result interesting in the application of this hydrogel as a biosensor or as an actuator, but also opens a broad range of possibilities of the use of this biomaterial in the biomedical field. Ingeniería Biomédica |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|