PROGNOSTIC FACTORS OF POSITIVE RESULTS OF MULTIFOCAL TRUS-GUIDED VESICOURETHRAL ANASTOMOSIS BIOPSY IN PATIENTS WITH BIOCHEMICAL RECURRENCE AFTER RADICAL PROSTATECTOMY
| Autor: | P. D. Demeshko, A. V. Karman, O. G. Sukonko, S. A. Krasny |
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| Jazyk: | ruština |
| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | Onkourologiâ, Vol 7, Iss 4, Pp 59-66 (2014) |
| ISSN: | 1996-1812 1726-9776 |
| Popis: | Purpose. To evaluate influence of clinical, biochemical and histological factors to detection rate of local recurrence following radical prostatectomy (RPE) using multifocal TRUS-guided vesicourethral anastomosis (VUA) biopsy.Material and methods. 59 patients with newly diagnosed biochemical recurrence (BR) after RPE were included into prospective study. All of them underwent multifocal TRUS-guided VUA biopsy. Сlinical variables (serum prostate-specifi c antigen [PSA] level and PSA kinetics, time RPE-BR, Gleason grade, stage after RPE and clinical findings) were evaluated. Logistic regression and receiver operating characteristic (ROC) curve analyses were performed.Results. The detection rate of local prostate recurrence with TRUS-guided VUA biopsy was 45,8 % (95 % CI 33,7–58,3). At multivariate analysis only PSA level at the moment of biopsy (≤ 1,5 ng/ml vs > 1,5 ng/ml) and time RPE-BR (≤ 15 months vs > 15 months) were significantly associated with positive results of multifocal TRUS-guided VUA biopsy (p < 0,05).Conclusion The detection rate of local prostate recurrence with TRUS-guided VUA biopsy depends on combination of independent predictors (PSA level at the moment of biopsy and time RPE—BR). |
| Databáze: | OpenAIRE |
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