A CONVENIENT SYNTHESIS AND CYTOTOXIC ACTIVITY OF 3-ARYL-5-PENTYL-1,2,4-OXADIAZOLES FROM CARBOXYLIC ACID ESTERS AND ARYLAMIDOXIMES UNDER SOLVENT-FREE CONDITIONS
| Autor: | PIMENTEL BARROS, CARLOS JONNATAN, CARDOSO DE SOUZA, ZILYANE, RUFINO DE FREITAS, JUCLEITON JOSÉ, NORBERTO DA SILVA, PAULO BRUNO, GADELHA MILITÃO, GARDENIA CARMEN, GONÇALVES DA SILVA, TERESINHA, RUFINO FREITAS, JULIANO CARLO, RUFINO DE FREITAS FILHO, JOÃO |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | Journal of the Chilean Chemical Society v.59 n.1 2014 SciELO Chile CONICYT Chile instacron:CONICYT Journal of the Chilean Chemical Society, Volume: 59, Issue: 1, Pages: 2359-2362, Published: MAR 2014 |
| Popis: | The synthesis of 3-aryl-5-pentyl-1,2,4-oxadiazoles from carboxylic acid esters and arylamidoximes in the presence of potassium carbonate is described. The reaction was carried out in a microwave oven without any solvent in much shorter time and in good yields. The structures of the synthesized compounds were elucidated using IR, ¹H and 13C NMR spectroscopy and elemental analysis and their antiproliferative activities was evaluated against three different human cell lines. |
| Databáze: | OpenAIRE |
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