Catalytic Asymmetric Reactions Involving the Seven-Membered Cyclic Imine Moieties Present in Dibenzo[b,f][1,4]oxazepines

Autor: De Munck, Lode, Vila Descals, Carlos, Pedro, José Ramón
Rok vydání: 2018
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Zdroj: De Munck, Lode Vila Descals, Carlos Pedro, José Ramón 2018 Catalytic Asymmetric Reactions Involving the Seven-Membered Cyclic Imine Moieties Present in Dibenzo[b,f][1,4]oxazepines European Journal of Organic Chemistry 2018 2 140 146
RODERIC. Repositorio Institucional de la Universitat de Valéncia
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DOI: 10.1002/ejoc.201701279
Popis: The dibenzo[b,f][1,4]oxazepine scaffold is a privileged structure in medicinal chemistry that displays a wide variety of biological and pharmacological activities. However, catalytic asymmetric methodologies for the synthesis of chiral dibenzo[b,f][1,4]oxazepine derivatives are scarce in the literature. This microreview presents an overview of enantioselective reactions in which these cyclic seven-membered imines are used as electrophiles, including their substrate scope, limitations and application to the synthesis of related compounds.
Databáze: OpenAIRE