A synthetic approach to ervatamine-silicine alkaloids. Enantioselective total synthesis of (-)-episilicine
| Autor: | Amat Tusón, Mercedes, Llor Brunés, Núria, Checa Castaño, Begoña, Molins i Grau, Elies, Bosch Cartes, Joan |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: | |
| Zdroj: | Dipòsit Digital de la UB Universidad de Barcelona |
| Popis: | Starting from an appropriate unsaturated phenylglycinol-derived oxazolopiperidone lactam, the synthesis of (-)-16-episilicine is reported, the key steps being a stereoselective conjugate addition, a stereoselective alkylation, and a ring-closing metathesis reaction. This represents the first enantioselective total synthesis of an alkaloid of the silicine group. |
| Databáze: | OpenAIRE |
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