Biodegradation of Synthetic Biphasic Calcium Phosphate and Biological Calcified Substratum by Cells of Hemopoietic Origin

Autor:	Soueidan, A., Gan, O. I., Jean-Michel BOULER, Gouin, F., Daculsi, G.
Rok vydání:	1995
Předmět:	musculoskeletal diseases Biphasic calcium phosphate ceramic cell culture methods trans mission electron microscopy multinucleated giant cells biodegradation scanning electron microscopy Biomedical Engineering and Bioengineering osteoclasis macrophages
Zdroj:	Cells and Materials Scopus-Elsevier
Popis:	Different types of osteoclastic cells (authentic osteoclasit from human giant cell tumor and bone marrow of newborn rats; newly-formed osteoclasts from adult rat bone marrow), giant multinucleated cells and macrophages were studied for their effect on synthetic and natural mineralized substrata. Biphasic calcium phosphate ceramic consisted of hydroxyapatite and beta tricalcium phosphate was chosen for in vitro experiments, and dentine served as a positive control for cell resorbing activity . Our results show the limited capacity of authentic and newly-formed osteoclasts to resorb synthetic ceramic as compared to that of natural substrata. In vitro cell-mediated biodegradation included also modifications of the synthetic substratum surface caused presumably by phagocytosis of the material.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::01730c8ef1697e0ac84f61423f971898 http://digitalcommons.usu.edu/cellsandmaterials/vol5/iss1/3 Zobrazit plný text záznamu