Interactions between lifestyle-related factors and the ApoE polymorphism on plasma lipids and apolipoproteins: The ears study
| Autor: | Boer, J.M.A., Ehnholm, C., Menzel, H.J., Havekes, L.M., Rosseneu, M., O'Reilly, D.S.J., Tiret, L. |
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| Přispěvatelé: | Gaubius Instituut TNO |
| Jazyk: | angličtina |
| Rok vydání: | 1997 |
| Předmět: |
Adult
Male Linoleic acid Heterozygote Adolescent Apolipoprotein E4 Saturated fatty acid Major clinical study Triacylglycerol Body Mass Index Apolipoproteins E Cigarette smoking Risk Factors Humans Alcohol consumption Apolipoprotein e Biology Apolipoprotein b Life Style Adiposity Priority journal Apolipoproteins B Genetic polymorphism Polymorphism Genetic Anthropometry Apolipoprotein e2 Physical activity Cholesterol oleate Apolipoprotein e3 nutritional and metabolic diseases Lipid Lifestyle Apolipoprotein E polymorphism Lipids Coronary Arteriosclerosis Apolipoprotein Lipid blood level Cholesterol Polyunsaturated fatty acid Phenotype Apolipoproteins Body mass lipids (amino acids peptides and proteins) Female Cholesterol Esters Controlled study Human |
| Zdroj: | Arteriosclerosis, Thrombosis, and Vascular Biology, 9, 17, 1675-1681 |
| Popis: | To elucidate how the apolipoprotein (apo)E polymorphism and modifiable factors interact in explaining plasma lipid and apolipoprotein levels, we studied 1448 young adults (18 to 26 years old), participating in the European Atherosclerosis Research Study (EARS). Venous blood was collected after an overnight fast. Modifiable factors, eg, body mass index (BMI), waist-to-hip ratio (WHR), tobacco and alcohol consumption, and physical activity, were determined by using standardized protocols. Associations of modifiable factors with apoE levels were homogeneous across apoE phenotypes. In contrast, correlations of BMI with total cholesterol and apoB levels, as well as correlations between WHR and apoB, were significantly (P |
| Databáze: | OpenAIRE |
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