Improvement of the synthesis of immunologic carbohydrate vaccines containing the tumor associated antigen CaMBr1

Autor:	Panza, L, Poletti, L, PROSPERI, DAVIDE, Canevari, S, Perico, ME
Přispěvatelé:	Panza, L, Poletti, L, Prosperi, D, Canevari, S, Perico, M
Rok vydání:	2001
Předmět:	globo-H immunologia CHIM/06 - CHIMICA ORGANICA MED/04 - PATOLOGIA GENERALE carbohydrates conjugate vaccine antitumorali CRM197 KLH sintesi organica BIO/10 - BIOCHIMICA complex mixtures
Zdroj:	European journal of organic chemistry 22 (2001): 4331–4336. info:cnr-pdr/source/autori:Panza L., (1) Poletti L., (2) Prosperi D., (3) Canevari S., (2) Perico M.E. (2)/titolo:Improvement of the synthesis of immunologic carbohydrate vaccines containing the tumor associated antigen CaMBr1/doi:/rivista:European journal of organic chemistry (Print)/anno:2001/pagina_da:4331/pagina_a:4336/intervallo_pagine:4331–4336/volume:22
Popis:	The simplified synthesis of a portion of Globo-H hexasaccharide, a saccharide antigen overexpressed by breast cancer cells, and its conjugation to two different immunogenic proteins are described. The conjugated vaccines, evaluated in a preclinical model, showed good immunogenic potential.
Databáze:	OpenAIRE
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