Lack of association between IL1A c.-889 C>T gene polymorphism and chronic periodontitis in subjects from Bahia, Brazil
| Autor: | Oliveira, Kamilla Menezes, Alcântara, Lucas Magalhães, Teixeira, Fernanda Gabriela, Mendonça, Samir Andrade, dos Santos, Djanilson Barbosa, Marques, Lucas Miranda, Amorim, Maise Mendonça, Gestinari, Raquel de Souza |
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| Jazyk: | portugalština |
| Rok vydání: | 2016 |
| Zdroj: | Arquivos em Odontologia; v. 51, n. 4 (2015) Arquivos em Odontologia; v. 51 n. 4 (2015) |
| ISSN: | 1516-0939 2178-1990 |
| Popis: | Aim: This study aimed to analyze the relationship between the polymorphism c.-889 C>T in the IL1A gene and periodontitis in subjects from Vitória da Conquista, Bahia, Brazil. Methods: Two hundred fifty-nine individuals were classified according to periodontitis diagnoses in cases and controls. Genomic DNA was extracted from buccal epithelial cells. Genotyping was performed by PCR-RFLP, followed by agarose gel electrophoresis. Data were analyzed using Chi-square, Fisher’s exact and Hosmer-Lemeshow tests. Results: In the individuals evaluated in this study, periodontitis was significantly associated with a low educational level (p = 0.024) and clinical variables, such as gingival bleeding (p = 0.019) and tooth mobility (p = 0.001). Among patients in the case group, the majority (72.88%) had a generalized form of periodontitis. The genotypic frequencies for IL1A c.–889 C>T between the case and control groups did not significantly differ (χ2 = 1.6983; p = 0.428). Conclusion: This study’s findings indicate the lack of association between periodontitis and the IL1A c -889 C>T gene polymorphism.Uniterms: Peridontitis. Genetic polymorphism. Interleukin-1. |
| Databáze: | OpenAIRE |
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